Creator and executive producer Neil Jordan said he recently decided not to proceed with a fourth season.
"I never thought I would make a cable series and have enjoyed every minute of it," said Jordan in a statement.
"For a variety of reasons we won't be doing a fourth season, but 'The Prince' (the final episode), when I wrote and shot it, did feel like an end of a journey for the family.
"Whatever bonded them as a family dies in this episode, and the center of the drama for me was always the family."
The show, which stars Jeremy Irons and shows Pope Alexander VI as a cunning and manipulative patriarch who builds a dynasty through corruption, was shot entirely on location in Budapest.
More Entertainment Headlines
Aasif Mandvi bridges East-West gap Billy Joel breaks Elton John’s record for Garden concerts Capsule reviews of the next week’s video releases, on DVD and Blu-ray Monday’s highlights on TV 5 things for Apple (and you) to keep in mind as Apple Music is launched Summer songs soak up the sunshine Jane Austen meets Singapore in this beach page-turner List of upcoming local book events
Our to-do list full of ideas for your weekend
Our new comment system is not supported in IE 7. Please upgrade your browser here.